N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide

Name	DDR1-IN-1
Synonyms	TL4-44 CS-1427 DDR-IN-1 DDR1-IN-1 DDR1 inhibitor 1 4-((4-ethylpiperazin-1-yl)methyl)-N-(4-methyl-3-((2-oxoindolin-5-yl)oxy)phenyl)-3-(trifluoromethyl)benzamide N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide Benzamide, N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-
CAS	1449685-96-4

Molecular Formula	C30H31F3N4O3
Molar Mass	552.59
Solubility	DMSO: ≥ 41 mg/mL
Storage Condition	-20℃
In vitro study	In U2OS cells, DDR1-IN-1 inhibited basal DDR1 autophosphorylation with an EC50 of 86 nM and a stronger inhibition of DDR1 autophosphorylation in the absence of collagen stimulation. In a panel of different cancer cell lines with gain-of-function mutations and/or overexpression of DDR1, DDR1-IN-1 did not inhibit cell proliferation at concentrations below 10 μm, while GSK2126458 will enhance the antiproliferative activity of DDR1-IN-1.

Last Update：2024-01-02 23:10:35

biological activity	DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor, with an IC50 of 105 nM, the selectivity is approximately 3-fold higher than for DDR2.
Target	Value
DDR1 (Cell-free assay)	105 nM
DDR2 (Cell-free assay)	413 nM

Last Update：2024-04-09 20:49:11

Product Name: DDR1-IN-1 Visit Supplier Webpage Request for quotation
CAS: 1449685-96-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: DDR1-IN-1 Visit Supplier Webpage Request for quotation
CAS: 1449685-96-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide Request for Quotation